For most Americans, the first experience with AI in healthcare won’t be in a hospital operating room—it will be at the first point of contact: a chatbot, a scheduling tool, or a symptom checker. This Ai65 flagship article explores how “first contact” will shape trust, reform, and the culture of care over the next 40 years. Human-first design is the key to adoption.
Healthcare systems are under pressure to cut costs while improving outcomes—goals that often feel at odds. This Ai65 briefing explores how AI can align financial sustainability with patient-first care, ensuring technology adoption is measured not only by efficiency but also by trust and clinical impact. Over the next 40 years, success will come from systems that deliver both margins and humanity.
The race to discover new drugs has always been long and costly. AI is changing that, pairing remarkable speed with human creativity to bring treatments to patients faster than ever before. This Ai65 briefing explores how AI can make drug discovery both a breakthrough business and a lifesaving engine for those in need over the next 40 years.


Artificial intelligence isn’t something organizations are deciding whether to adopt — it’s already here, unevenly and irreversibly. Every business is now evolving their AI, celebrating and building on learnings they already have. Ai65 helps leaders see the terrain clearly, apply the right kind of AI at the right moment, and prevent inefficiencies.