Human beings evolved to manage small numbers: a village, a harvest, a horizon. But modern life runs on big numbers — billions of people, trillions of dollars, exabytes of data. These scales overwhelm our brains, tempt us into shortcuts, distort our pursuit of truth, and harden tribal loyalties. Too often, we abandon judgment — not because we are weak, but because we are human. In this Ai65 flagship essay, we explore the 40 year horizon on Ai helping us see more and hopefully do more.
For most Americans, the first experience with AI in healthcare won’t be in a hospital operating room—it will be at the first point of contact: a chatbot, a scheduling tool, or a symptom checker. This Ai65 flagship article explores how “first contact” will shape trust, reform, and the culture of care over the next 40 years. Human-first design is the key to adoption.
Healthcare systems are under pressure to cut costs while improving outcomes—goals that often feel at odds. This Ai65 briefing explores how AI can align financial sustainability with patient-first care, ensuring technology adoption is measured not only by efficiency but also by trust and clinical impact. Over the next 40 years, success will come from systems that deliver both margins and humanity.
The race to discover new drugs has always been long and costly. AI is changing that, pairing remarkable speed with human creativity to bring treatments to patients faster than ever before. This Ai65 briefing explores how AI can make drug discovery both a breakthrough business and a lifesaving engine for those in need over the next 40 years.

